San Diego to Palm Springs Posted on 2021-Nov-26 by adohertyh The route over the mountains between San Diego and Palm Springs, CA 74, leads down this incredible twisting spiral of two-lane blacktop. Far in the distance, the twinkling lights of the desert valley await night travelers. Share this: Click to share on X (Opens in new window) X Click to share on Facebook (Opens in new window) Facebook Click to share on Reddit (Opens in new window) Reddit Like Loading...